Podocyte and tubular involvement in AngioJet-induced kidney injury
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چکیده
منابع مشابه
Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice
Background: Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial–mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in kidney tubular injury.Methods: A hyperuricemia model was performed in male Swiss background mice (3 months old,...
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In our study [4], FGF2 and FGF2-neutralizing antibody were administered to animals with PAN nephropathy. After PAN injection, recombinant FGF2 Introduction (group F), FGF2-neutralizing antibody (group M) or the same volume of physiological saline (group C) was Recent studies point to an important role for podocytes injected for 4 days via the tail vein, and the animals in the physiology and pat...
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BACKGROUND Fabry disease. an X-linked deficiency of α-galactosidase A coded by the GLA gene, leads to intracellular globotriaosylceramide (GL-3) accumulation. Although less common than in males, chronic kidney disease, occurs in ∼ 15% of females. Recent studies highlight the importance of podocyte injury in Fabry nephropathy development and progression. We hypothesized that the greater the % of...
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It has recently become clear that initial glomerular injury affects glomerular visceral epithelial cells (also called as podocytes) as important target cells for progression of chronic kidney disease (CKD) and end-stage kidney disease. Podocytes are injured in many human kidney diseases including minimal change disease, focal segmental glomerulosclerosis, diabetic nephropathy, membranous nephro...
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Intracellular iron reportedly mediates many forms of tissue injury, including ischemic and myohemoglobinuric acute renal failure. This action may be explained by the ability of iron to catalyze the formation of the highly toxic hydroxyl radical (.OH) from H202 via the Fenton/Haber-Weiss reactions. To assess whether renal tubular myoglobin/iron loading, induced by a physiological mechanism (endo...
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ژورنال
عنوان ژورنال: Clinical Kidney Journal
سال: 2019
ISSN: 2048-8513
DOI: 10.1093/ckj/sfz104